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sparsentan will lower the extent or outcome of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Observe. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and minimizes efficacy related to these substrates.Hou et al (2005) analyzed the autonomic consequences of modafinil in people. They uncovered that moda